Evaluation and Diagnosis of Chest Pain

Authoring Organizations

Publication Month/Year

October 28, 2021

Last Updated Month/Year

July 24, 2023

Document Type


External Publication Status


Country of Publication


Document Objectives

This executive summary of the clinical practice guideline for the evaluation and diagnosis of chest pain provides recommendations and algorithms for clinicians to assess and diagnose chest pain in adult patients.

Target Patient Population

Adults with chest pain

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Emergency care, Home health, Hospital, Medical transportation

Intended Users

Paramedic emt, nurse, nurse practitioner, physician, physician assistant


Diagnosis, Assessment and screening, Management

Diseases/Conditions (MeSH)

D056586 - Acute Chest Syndrome, D002637 - Chest Pain


chest pain

Source Citation

Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, Blankstein R, Boyd J, Bullock-Palmer RP, Conejo T, Diercks DB, Gentile F, Greenwood JP, Hess EP, Hollenberg SM, Jaber WA, Jneid H, Joglar JA, Morrow DA, O'Connor RE, Ross MA, Shaw LJ. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021 Oct 28:CIR0000000000001029. doi: 10.1161/CIR.0000000000001029. Epub ahead of print. PMID: 34709879.

Supplemental Methodology Resources

Data Supplement, Methodology Supplement


Number of Source Documents
Literature Search Start Date
November 11, 2017
Literature Search End Date
May 1, 2020